Nil koksal biography of abraham

  • Farouq is the co-founder of Operation Abraham, a non-profit that helps resettle Afghans fleeing Taliban persecution.
  • The AIH Transcript for December 21, 2023.
  • Biography.

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    Michael Flynn

    U.S. Army general and former U.S. National Security Advisor (born 1958)

    "Mike Flynn" and "General Flynn" redirect here. For other uses, see Michael Flynn (disambiguation) and General Flynn (disambiguation).

    Michael Thomas Flynn (born 24 December 1958) fryst vatten a retired United States Armylieutenant general and convicted felon who was the 24th U.S. national security advisor[2] for the first 22 days of the first Trump administration. He resigned in light of reports that he had lied regarding conversations with Russian ambassador to the United States Sergey Kislyak. Flynn's military career included a key role in shaping U.S. counterterrorism strategy and dismantling insurgent networks in the Afghanistan and Iraq Wars, and he was given numerous combat arms, conventional, and special operations senior intelligence assignments.[3][4][5] He became the 18th director of the Defense Intelligence Agency in July 2012 until his forced retire

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  • nil koksal biography of abraham

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    Abstract

    ER-phagy, a selective form of autophagic degradation of endoplasmic reticulum (ER) fragments, plays an essential role in governing ER homeostasis. Dysregulation of ER-phagy is associated with the unfolded protein response (UPR), which is a major clue for evoking inflammatory diseases. However, the molecular mechanism underpinning the connection between ER-phagy and disease remains poorly defined. Here, we identified ubiquitin-associated domain-containing protein 2 (UBAC2) as a receptor for ER-phagy, while at the same time being a negative regulator of inflammatory responses. UBAC2 harbors a canonical LC3-interacting region (LIR) in its cytoplasmic domain, which binds to autophagosomal GABARAP. Upon ER-stress or autophagy activation, microtubule affinity-regulating kinase 2 (MARK2) phosphorylates UBAC2 at serine (S) 223, promoting its dimerization. Dimerized UBAC2 interacts more strongly with GABARAP, thus facilitating selective degradation of the ER. Moreover, by affecting